TTKG Calculator - Transtubular Potassium Gradient

TTKG Calculator

Calculate transtubular potassium gradient for renal potassium handling assessment

Medical Disclaimer

This calculator is for educational purposes only. Always consult a healthcare professional for medical advice and diagnosis.

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TTKG Calculation
About TTKG

The transtubular potassium gradient (TTKG) assesses renal potassium handling and helps differentiate causes of hyperkalemia.

TTKG Formula:

TTKG = (Urine K / Serum K) × (Serum Osm / Urine Osm)

Interpretation:
  • <3: Inadequate K+ secretion
  • 3-7: Normal K+ handling
  • >7: Excessive K+ secretion
Clinical Uses:
  • • Hyperkalemia evaluation
  • • Hypokalemia assessment
  • • Renal function evaluation
  • • Medication effects
Limitations:
  • • Requires urine collection
  • • Affected by hydration
  • • Diurnal variation
  • • Medication interference
Professional Resources:
  • • Nephrologist
  • • Endocrinologist
  • • Primary care physician
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